Paget's disease of bone.

نویسنده

  • R Smith
چکیده

paid study leave is not available and child care expenses may also have to be met. Since April 1991 regional postgraduate deans have been given funds for postgraduate medical education for those on the scheme, and the amount allocated to each doctor varies across the regions but is usually inadequate to cover the required seven educational sessions. Since the inception of the postgraduate education allowance in 1990 for principals the cost of providing courses has risen rapidly. The need for continuing postgraduate education for a doctor on the retainer scheme is as great as that for any general practitioner. A mechanism must exist whereby the cost barrier can be overcome either by giving a free "pass" for educational activities, increasing the amounts payable by the postgraduate deans, or increasing the retainer fee. Doctors whose domestic commitments make them temporarily unable to devote themselves fully to their medical careers need an effective and fair deal.

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Quantification and comparison of bone-specific alkaline phosphatase with two methods in normal and paget’s specimens

Background: Bone-specific alkaline phosphatase (BAP) is synthesized by the osteoblasts and is presumed to be involved in the calcification of bone matrix, though its precise role in the formation process is unknown. The aim of the present study was to measure the BAP activity in Paget's and normal specimens by two different techniques. Methods: Total ALP (TAP) as well as BAP activity-measuring ...

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in the treatment of Paget's bone disease. Lancet 1971 ;i: 1 139-43. 5 Smith R, Russell RGG, Bishop MC, Woods CG, Bishop M. Paget's disease of bone. Experience with a diphosphonate (disodium etidronate) in treatment. QJ7Med 1972;42:235-56. 6 Douglas DL, Duckworth T, Kanis JA, Jefferson AA, Martin TJ, Russell RGG. Spinal cord dysfunction in Paget's disease of bone. Has medical treatment a vascula...

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Pathobiology of Paget's Disease of Bone

Paget's disease of bone is characterized by highly localized areas of increased bone resorption accompanied by exuberant, but aberrant new bone formation with the primary cellular abnormality in osteoclasts. Paget's disease provides an important paradigm for understanding the molecular mechanisms regulating both osteoclast formation and osteoclast-induced osteoblast activity. Both genetic and e...

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Paget's disease of bone presented as normal pressure hydrocephalus: A case report and review of literature

BACKGROUND Paget's disease is a focal bone disorder manifested as bone overgrowth and disrupted bone integrity as a result of accelerated bone remodelling rate. Rarely, Paget's disease of the base of the skull results in hydrocephalic dementia, and the triad of normal pressure hydrocephalus syndrome is a much more scarce entity. CASE REPORT Herein, we report an elderly woman who presented in ...

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Polyostotic Paget's disease.

Paget's disease of bone is a common metabolic bone disease in most of the European countries. The disease has distinct geographical distribution being rare in Asia. We report Paget's disease in a 70 years old Pakistani male who presented with history of pain in right leg with difficulty in walking for the last 5 months. Plain X-ray raised suspicion of Paget's disease of bone. Technetium-99m MDP...

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References BARRY, H.C. (1961) Sarcoma in Paget's disease of bone in Australia. J. Bone Jt Surg. 43A, 1122. JAFFE, H.L. (1933) Paget's disease of bone. Arch. Path. 15, 83. LAKE, M. (1951) Studies of Paget's disease (osteitis deformans). J. Bone Jt Surg. 33B, 323. PORRETTA, C.A., DAHLIN, D.C. & JANES, J.M. (1957) Sarcoma in Paget's disease of bone. J. Bone Jt Surg. 39A, 1314. PRICE, C.H.G. (1962)...

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عنوان ژورنال:
  • BMJ

دوره 305 6866  شماره 

صفحات  -

تاریخ انتشار 1992